Estatina | referencias


  1. Arrigoni, Elena; Del Re, Marzia; Fidilio, Leonardo; Fogli, Stefano; Danesi, Romano; Di Paolo, Antonello (enero de 2017). «Pharmacogenetic Foundations of Therapeutic Efficacy and Adverse Events of Statins» [Fundamentos farmacogenéticos de la eficacia terapéutica y los eventos adversos de las estatuas]. Int J Mol Sci (en inglés) (Multidisciplinary Digital Publishing Institute (MDPI)) 18 (1): 104. 28067828. 10.3390/ijms18010104. Consultado el 30 de julio de 2017. 
  2. Doyle, Meagan; Bhimji, Steve (febrero de 2017). «Statin Medications» [Medicamentos de estatina]. StatPearls [Internet] (en inglés) (Florida: StatPearls Publishing). 28613690. Consultado el 30 de julio de 2017. 
  3. Amando Martin-Zurro, J. F. Cano Pérez Atención primaria (en español). Publicado por Elsevier España, 2003; pág 811. ISBN 84-8174-650-9
  4. a b Endo, Akira (mayo de 2010). «A historical perspective on the discovery of statins» [Una perspectiva histórica del descubrimiento de las estatinas]. Proc Jpn Acad Ser B Phys Biol Sci (en inglés) (Japón: The Japan Academy) 86 (5): 484-493. 20467214. 10.2183/pjab.86.484. Consultado el 30 de julio de 2017. 
  5. Endo, Akira (octubre de 2004). «The origin of the statins» [El origen de las estatinas]. Atherosclerosis Supplements (en inglés) (Tokio, Japón: Elsevier) 5 (3): 125-130. 15531285. 10.1016/j.atherosclerosissup.2004.08.033. Consultado el 30 de julio de 2017. 
  6. Endo, Akira (noviembre de 1992). «The discovery and development of HMG-CoA reductase inhibitors» [El descubrimiento y el desarrollo de los inhibidores de la HMG-CoA reductasa]. Journal of Lipid Research (en inglés) (Tokio, Japón: American Society for Biochemistry and Molecular Biology) 33 (11): 1569-1582. 1464741. Consultado el 30 de julio de 2017. 
  7. a b c d Agencia española de medicamentos y productos sanitarios. Información de fichas técnicas autorizadas. Enlace consultado el 30 de octubre de 2008.
  8. a b c d e Daily Med. Current Medication Information. Disponible en [1]
  9. De Angelis G.. The influence of statin characteristics on their safety and tolerability. Int J Clin Pract. 2004;58:945-55
  10. a b c Alonso Karlezi,R , Mata Pariente,N , Mata López,P;Control de las hiperlipemias en la práctica clínica Rev Esp Cardiol 2007; 6: 24 - 35 ISSN : 1579-2242 Disponible en [2]
  11. Nissen S, Tuzcu M, Schoenhagen P, Brown BG, Ganz P, Vogel RA, et al.. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis. JAMA. 2004;291:1071-80.
  12. Frohlich ED. Promise of prevention and reversal of target organ involvement in hypertension. J Renin Angiotensin Aldosterone Syst. 2001;2(Suppl 1):2–7.
  13. Kallen, J. et al. Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. J Mol Biol 1999; 292, 1–9.
  14. a b Lionel H. Opie, Bernard J. Gersh, John P DiMarco. Farmacos Para El Corazon (en español). Publicado por Elsevier España, 2005; pág 343. ISBN 84-8174-865-X
  15. Packard C, Caslake M, Pastor J. The role of small, dense low density lipoprotein (LDL): a new look. Int J Cardiol. 2000 Jun 30; 74 Suppl 1: S17-22 Disponible en [3] PMID 10856769
  16. Davignon J.. The cardioprotective effects of statins. Curr Atheroscler Rep. 2004;6:27-35
  17. Liao JK.. Isoprenoids as mediators of the biological effects of statins. J Clin Invest. 2002;110:285-8
  18. Denicola A, Batthyany C, Lissi E, et al. Diffusion of nitric oxide into low density lipoprotein. J Biol Chem 2002;277:932-6.
  19. Lacoste L, Lam JY, Hung J, et al. Hyperlipidemia and coronary disease. Correction of the increased thrombogenic potential with cholesterol reduction. Circulation 1995; 92:3172–77.
  20. Essig M, Nguyen G, Prie D, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylation and Rho proteins. Circ Res 1998; 83:683–90.
  21. Hernandez-Perera O, Perez-Sala D, Navarro-Antolin J, et al. Effects of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J Clin Invest 1998;101:2711–19.
  22. Cai H, Harrison DG. Endotelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 2000;87:840–44.
  23. Wassmann S, Laufs U, Baumer AT,Muller K, et al. HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species. Hypertension 2001;37:1450–57.
  24. Laufs U,Marra D, Node K, Liao JK. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1). J Biol Chem 1999; 274:21926– 31.
  25. Ross R. Atherosclerosis is an inflammatory disease. Am Heart J 1999;138:S419–20.
  26. Vaughan CJ, Gotto AM Jr., Basson CT. The evolving role of statins in the management of atherosclerosis. J Am Col. Cardiol .2000 35:1–10.
  27. Ridker PM, Cushman M, Stampfer MJ, et al. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. New Engl J Med 1997; 336:973–79.
  28. Torzewski J, Bowyer DE,Waltenberger J, et al. Processes in atherogenesis: complement activation. Atherosclerosis 1997;132:131–38.
  29. Danenberg HD, Szalai AJ, Swaminathan RV, et al. Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice. Circulation 2003;108: 512–15.
  30. Aikawa M, Rabkin E, Sugiyama S, et al. An HMGCoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro. Circulation 2001;103:276–83.
  31. Kannel WB, Feinleib M, McNamara PM, Garrison RJ, Castelli WP. An investigation of coronary heart disease in families: the Framingham Offspring Study. Am J Epidemiol. 1979;110:281–290 Disponible en [4] (enlace roto disponible en última versión).
  32. Keys A. Seven Countries: A Multivariate Analysis of Death and Coronary Heart Disease. Cambridge, Mass: Harvard University Press; 1980
  33. Iso H, Jacobs DR Jr.,Wentworth D, et al. Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trial. New Engl J Med 1989;320:904–10.
  34. Respecto al Lipid Research Clinics Coronary Primary Prevention, pueden consultarse los siguientes artículos:
    • Lipid Research Clinics Program: The Coronary Primary Prevention Trial: design and implementation. J Chron Dis 32: 609, 1979
    • Lipid Research Clinics Program: The Lipid Research Clinics Coronary Primary Prevention Trial. I. Reduction in incidence of coronary heart disease. JAMA 251: 351, 1984
    • Lipid Research Clinics Program: The Lipid Research Clinics Coronary Primary Prevention Trial. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA 251: 365, 1984
  35. Respecto al Helsinki Heart, pueden consultarse los siguientes artículos:
    • Mänttäri M, Elo O, et al. The Helsinki Heart Study: basic design and randomization procedure. Eur Heart J. 1987 Oct;8 Suppl I:1-29.
    • Manninen V, Elo MO, et al.Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study.: JAMA. 1988 Aug 5;260(5):641-51.
    • Manninen V, Huttunen JK et al. Relation between baseline lipid and lipoprotein values and the incidence of coronary heart disease in the Helsinki Heart Study. Am J Cardiol. 1989 May 2;63(16):42H-47H.
  36. Ian Ford, Ph.D., Heather Murray, M.Sc.,et al , for the West of Scotland Coronary Prevention Study Group. Long-Term Follow-up of the West of Scotland Coronary Prevention StudyN Engl J Med 2008; 358:193-195, Jan 10, 2008.Disponible en la web en [5]
  37. Downs, JR.Clearfield, M. Weiss, S. et al. Primary Prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of de AFCAPS/TexCAPS. JAMA, 1998;279:1615-1622
  38. Colhoun HM, Betteridge DJ, et al, on behalf of the CARDS investigators. Primary prevetion of cardiovacular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controllede trial. N Engl J Med 2004;364:685-96.
  39. Ballantyne CM, Blazing MA, et al. Effect on high-density lipoprotein cholesterol of maximum dose simvastatin and atorvastatin in patients with hypercholesterolemia: results of the Comparative HDL Efficacy and Safety Study (CHESS). Am Heart J 2003; 146:862-9.
  40. Albert MA, Danielson E, Rifai N, Ridker PM, . Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study. JAMA. 2001;286:64-70. (PMID 11434828)
  41. Ridker PM. Rosuvastatin in the primary prevention of cardiovascular disease among patients with low levels of low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: rationale and design of the JUPITER trial. Circulation 2003; 108: 2292–2297.
  42. Jones P, Davidson M, Stein E, et al. Comparison of the Efficacy and Safety of Rosuvastatin Versus Atorvastatin, Simvastatin, and Pravastatin Across Doses (STELLAR Trial). Am J Cardiol 2003;92:152-160.
  43. Bays HE, Dujovne CA,et al. ADVOCATE Group. Comparison of once-daily, niacin extended-release/lovastatin with standard doses of atorvastatin and simvastatin (the ADvicor Versus Other Cholesterol-Modulating Agents Trial Evaluation [ADVOCATE]). Am J Cardiol 2003;91:667–72.
  44. Willich SN, Müller-Nordhorn J, Sonntag F, et al. Economic evaluation of a compiance-enhancing intervention in patients with hypercholesterolaemia: Design and baseline results of the open label primairy care study: rosuvastatin bases compliance initiatives to achievements of LDL goals (ORBITAL) study: Am Heart J 2004; 148:1060-1067
  45. B Jacotot, J D Banga, P Pfister, and M Mehra Efficacy of a low dose-range of fluvastatin (XU 62-320) in the treatment of primary hypercholesterolaemia. A dose-response study in 431 patients. The French-Dutch Fluvastatin Study Group. Br J Clin Pharmacol. 1994 September; 38(3): 257–263. Disponible en [6]
  46. The Scandinavian Simvastatin Survival Study Group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994;344:1383-1389
  47. Pedersen, T.R., L.Wilhelmsen, O.Faergeman, et al. Follow-up study of patients randomized in the Scandinavian Simvastatin Survival Study (4S) of cholesterol lowering. Am J Cardiol 2000;86:257-262
  48. Sacks FM, Pfeffers MA, Moye LA, et al. The effect of pravastatin of coronary events after miocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrents Events Trial investigator. N.Eng.J.Med. 1996;335:1001-1009
  49. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998;339:1349–57.Disponioble en la web en «Copia archivada». Archivado desde el original el 12 de febrero de 2009. Consultado el 31 de octubre de 2008. 
  50. Collins R, Armitage J, Parish S, Sleigh P, Peto R, Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet 2003;361: 2.005-16.
  51. Schwartz GG, Olsson AG, Ezekowitz MD, Ganz P, Oliver MF, Waters, et al.. Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study Investigators. The effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled study. JAMA 2001;285:1711-8. Disponible en [7]
  52. Sever PS, Dahlöf B, Poulter NR, et al, for the ASCOT investigators. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial- Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 2003;361:1.149-58.
  53. Cannon CP, Braunwald E, et al, for the Pravastatin or Atorvastatin Evaluation and Infection therapy-Thrombolysis in myocardial Infarction 22 Investigators. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 2004;350:1.495-504 Disponible en [8]
  54. 11. LaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart JC, et al, for the Treating to New Targets (TNT) investigators. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med 2005;352:1425-35 Disponible en [9]
  55. Olsson AG, Eriksson M, et al. A 52-week, multicenter, randomized, parallel-group, double-blind, double-dummy study to assess the efficacy of atorvastatin and simvastatin in reaching low-density lipoprotein cholesterol and triglyceride targets: the treat-to-target (3T)study. Clin Ther 2003;25:119-38
  56. ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). JAMA 2002;288:2.998-3.007. Disponible en [10]
  57. Stalenhoef AFH, Ballantyne CM, Sarti, C et al. A Comparative study with rosuvastatin in subjects with METabolic Syndrome: rationale and design of the COMETS study. Diabetes Metab 2003;29(Suppl): 4S318 Abstract 2559. Disponible en [11]
  58. Faergeman O, Sosef F, Duffield E, On behalf of the ECLIPSE Study Investigators. Efficacy and tolerability of rosuvastatin and atorvastatin when force-titrated in high-risk patients: results from the ECLIPSE Study. Atheroscler Suppl 2006;7:580.
  59. Ballantyne CM, Weiss R, Moccetti T, et al. EXPLORER Study Investigators. Efficacy and safety of rosuvastatin 40 mg alone or in combination with ezetimibe in patients at high risk of cardiovascular disease (results from the EXPLORER study). Am J Cardiol 2007;99:673–80
  60. Stender S, Schuster H, Barter P, et al. Comparison of rosuvastatin with atorvastatin, simvastatin and pravastatin in achieving cholesterol goals and improving plasma lipids in hypercholesterolaemic patients with or without the metabolic syndrome in the MERCURY I trial. Diabetes, Obesity and Metabolism 2005; 7(4):430-438.
  61. Ballantyne CM, Raichlen JS, Cain VA, et al. Effect of switching high- and very high-risk patients to rosuvastatin from atorvastatin or simvastatin on achievement of new ATP III goals: MERCURY II. Atherosclerosis Supplement 2005;6(1): 101
  62. Clearfield M, Kallend D, Palmer M, et al. Efficacy and safety of rosuvastatin 10mg versus atorvastatin 20mg: Results of the PULSAR study. Atherosclerosis Supplements 2005;6(1): 104
  63. Leiter LA, Palmer M, Sosef F et al. Rosuvastatin 40 mg versus atorvastatin 80 mg in high-risk patients with hypercholesterolaemia: results of the POLARIS study at 8 and 26 weeks. Eur Heart J 2005; 26: (Abstract Supplement):581, (Abs P3503)
  64. Fellström B, Zannad F, Schmieder R et al. Effect of rosuvastatin on outcomes in chronic haemodialysis patients — baseline data from the AURORA study. Atheroscler Suppl 2006;7(3):578, Abs Th-P16:387.
  65. Strandberg TE, Feely J, Sigurdsson EL. DISCOVERY: A comparison of the efficacy and safety of rosuvastatin and atorvastatin in high-risk subjects with hypercholesterolaemia. International Journal Clinical Practice 2005;59(Suppl 148):3.
  66. Berne,C and Siewert,A for the URANUS study investigators. Comparison of rosuvastatin and atorvastatin for lipid lowering in patients with type 2 diabetes mellitus: results from the URANUS study. Cardiovascular Diabetology 2005, 4:7 Disponible en [12]
  67. Betteridge, DJ and Gibson, JM. Effects of rosuvastatin on lipids, lipoproteins and apolipoproteins in the dyslipidaemia of diabetes. Diabetic Medicine Volume 24 Issue 5, Pages 541 - 549
  68. Campeau, L Knatterud, GL et al. The Post Coronary Artery Bypass Graft Trial Investigators. The Effect of Aggressive Lowering of Low-Density Lipoprotein Cholesterol Levels and Low-Dose Anticoagulation on Obstructive Changes in Saphenous-Vein Coronary-Artery Bypass Grafts. N Engl J Med 1997; 336:1839-1840, Jun 19, 1997 Disponible en [13]
  69. Pitt B, Waters D, et al. Aggressive Lipid-Lowering Therapy Compared with Angioplasty in Stable Coronary Artery Disease. N Engl J Med 1999;341:70 Disponible en [14]
  70. Barth JD, Zonjee al. The REGRESS Research Group. Regression growth evaluation statin study (REGRESS): study design and baseline characteristics in 600 patients. Can J Cardiol. 1992 Nov;8(9):925-32.
  71. Furberg,CD Adams Jr, HP et al. Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group. Circulation. 1994;90:1679-1687 Disponible en [15]
  72. Waters, D. Higginson, L. et al. Effects of monotherapy with an HMG-CoA reductase inhibitor on the progression of coronary atherosclerosis as assessed by serial quantitative arteriography. The Canadian Coronary Atherosclerosis Intervention Trial. Circulation 1994;89:959-68 Disponible en [16]
  73. Waters D, Higginson L, et al. Effects of cholesterol lowering on the progression of coronary atherosclerosis in women: a Canadian Coronary Atherosclerosis Intervention Trial (CCAIT) substudy.Circulation 1995;92:2404-10 Disponible en [17]
  74. Pitt B.; Mancini GBJ. et al. Pravastatin limitation of atherosclerosis in the coronary arteries (PLAC I) : reduction in atherosclerosis progression and clinical events. Journal of the American College of Cardiology. 1995, vol. 26, no5, pp. 1133-1139 ISSN 0735-1097
  75. Crouse J. R. ; Byington R. P. Pravastatin, lipids, and atherosclerosis in the carotid arteries (PLAC-II) Am j card. 1995, vol. 75, no7, pp. 455-459
  76. Salonen, R , Nyssonen, K et al. The Kuopio Atherosclerosis Prevention Study (KAPS): effect of pravastatin treatment on lipids, oxidation resistance of lipoproteins, and atherosclerotic progression. Am-J-Cardiol. 1995 Sep 28; 76(9): 34C-39C
  77. David H. Blankenhorn; Stanley P et al. The MARS Research Group. Coronary Angiographic Changes with Lovastatin Therapy: The Monitored Atherosclerosis Regression Study (MARS). [18]
  78. Smilde TJ, Wissen S, Wollersheim H, et al. Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. Lancet 2001;357:577–81
  79. Hedblad B, Wikstrand J, et al. Low-dose metoprolol CR/XL and fluvastatin slow progression of carotid intima-media thickness: Main results from the Beta-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS). Circulation. 2001 Apr 3;103(13):1721-6.
  80. Sirtori, C.R. , Bianchi, G.Pravastatin intervention trial on carotid artery atherosclerosis in patients with mild hypercholesterolemia: the CAIUS study . The International Journal of Cardiac Imaging Volume 11, Supplement - 2 / junio de 1995. pp 119-124
  81. Yasunori Sawayama, Chie Shimizu, et al. Fukuoka atherosclerosis trial (FAST)Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hypercholesterolemia J Am Coll Cardiol, 2002; 39:610-616 Disponible en [19]
  82. Taylor, AJ; Kent, SM; et al.ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol. A Randomized Trial Comparing the Effects of Atorvastatin and Pravastatin on Carotid Intima Medial Thickness Circulation. 2002;106:2055. Disponible en [20]
  83. Taylor, AJ; Kent, SM; et al.Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2 A Double-Blind, Placebo-Controlled Study of Extended-Release Niacin on Atherosclerosis Progression in Secondary Prevention Patients Treated With Statins. Circulation. 2004;110:3512-3517 Disponible en [21]
  84. Steven E. Nissen; E. Murat Tuzcu, et al. for the REVERSAL Investigators Effect of Intensive Compared With Moderate Lipid-Lowering Therapy on Progression of Coronary Atherosclerosis. A Randomized Controlled Trial JAMA. 2004;291:1071-1080. Disponible en [22]
  85. Pedersen,TR.; Faergeman, O. et al. for the IDEAL study group. High-Dose Atorvastatin vs Usual-Dose Simvastatin for Secondary Prevention After Myocardial Infarction. JAMA. 2005;294:2437-2445. Disponible en [23]
  86. Nissen S. Design and methodology of a study to evaluate the effect of rosuvastatin on intravascular ultrasound-derived coronary atheroma burden: The ASTEROID study. Atherosclerosis Supplements 2003;4(2);27
  87. Steven E. Nissen, MD et al. The ASTEROID Trial. Effect of Very High-Intensity Statin Therapy on Regression of Coronary Atherosclerosis.JAMA. 2006;295:
  88. Crouse JR 3rd, Raichlen JS, Riley WA, et al. METEOR Study Group. Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR Trial. JAMA 2007;297:1344–53. Disponible en [24]
  89. Hatsukami TS, Zhao XQ, Yuan C, et al. Study design for a randomized, double-blind trial to assess the effect of 24 months of dosing with rosuvastatin on progression of carotid artery atheroma in moderately hypercholesterolemic patients with asymptomatic carotid stenosis. Atherosclerosis Supplements 2001;2(2):47-8
  90. Lee,CH; de Feyter,P et al. Beneficial effects of fluvastatin following percutaneous coronary intervention in patients with unstable and stable angina: results from the Lescol intervention prevention study (LIPS) Heart. 2004 October; 90(10): 1156–1161. doi: 10.1136/hrt.2003.027284. Disponible en [25]
  91. Zheng Zhou, Elham Rahme et al. Effectiveness of statins for secondary prevention in elderly patients after acute myocardial infarction: an evaluation of class effect.CMAJ. 2005 April 26; 172(9): 1187–1194. Disponible en [26]
  92. Respecto a estudios del papel de las estatinas en la osteogénesis pueden consultarse:
    • Mohammed H. Moghadasian, Jiri J. Frohlich, Statins and bonesCan.Med.As.Jour. • MAR. 20, 2001; 164 (6) Disponible en [27]
    • Meier CR, Schlienger RG, Kraenzlin ME, Schlegel B, Jick H.HMG-CoA
    reductase inhibitors and the risk of fractures. JAMA 2000; 283:3205-10.
    • Wang PS, Solomon DH, Mogun H, Avorn J. HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients. JAMA 2000; 283:3211-6.
    • Chan KA, Andrade SE, Boles M, Buist DS, Chase GA, Donahue JG, Goodman MJ, Gurwitz JH, LaCroix AZ, Platt R. Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women. Lancet 2000; 355:2185-8.
    • Van Staa TP, Wegman S, de Vries F, Leufkens B, Cooper C.Use of statins
    and risk of fractures. JAMA 2001; 285:1850-5.
    • LaCroix AZ, Cauley JA, Jackson R y col. Does statin use reduce risk of
    fracture in postmenopausal women? J Bone Miner Res 2000; 15 (suppl1): S 155.
  93. Simons M, Schwarzler F, Lutjohann D, von Bergmann K, Beyreuther K, Dichgans J, Wormstall H, Hartmann T, Schulz JB. Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial. Ann Neurol. 2002 Sep;52(3):346-50.
  94. Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA. Statins and the risk of dementia. Lancet. 2000 Nov 11;356(9242):1627-31.
  95. Michael Donnino and Michael Cocchi, Beth Israel Deaconess Medical Center. Boston, Massachusetts Study of Statin Therapy in the Treatment of Sepsis Estudio randomizado doble ciego iniciado en febrero del 2008. Información disponible en [28]
  96. Danai Khemasuwan, M.D et al. CHEST 2008: Statins Lower Risk of Deep Vein Thrombosis. Study of patients with solid organ tumors associates statins with a nearly threefold lower risk
  97. E Galli y L Feijoo. CITOCROMO P-450 Y SU IMPORTANCIA CLÍNICA (enlace roto disponible en última versión). (en español). Revista de Neuro-Psiquiatría 2002; 65: 187-201. Último acceso 4 de marzo, 2008.
  98. a b c Véase Guía de Prescripción Terapéutica. Información de medicamentos autorizados en España.
  99. Laporte JR (director). Estatinas: ¿nos pasamos de la raya?. Butlletí Groc. 2013; 26(3):9-12.
  100. Miller M, Dobs A, Yuan Z, Battisti WP, Borisute H, Palmisano J. Effectiveness of simvastatin therapy in raising HDL-C in patients with type 2 diabetes and low HDL-C. Curr Med Res Opin. 2004 Jul;20(7):1087-94.
  101. Davidson MH.. Safety profiles for HMG-CoA reductase inhibitors. Drugs. 2001;61:1917-26.
  102. Laporte JR (director). Estatinas: la otra cara de la moneda. Butlletí Groc. 2013; 26(4): 13-16.
  103. Thompson P, Clarkson P, Karas R.. Statin-associated myopathy. JAMA. 2003;289:1681-90.
  104. Baigent C, Keech A et al. Cholesterol Treatment Trialists' (CTT) Collaborators. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet. 2005 Oct 8;366(9493):1267-78
  • Pascuzzo Lima, C; Farmacología endocrina y metabólica, en Farmacología básica, vol. VIII. Disponible en [29]
  • Macin, S.M.; Drogas utilizadas en el tratamiento de las dislipoproteinemias en Farmacología de Malgor-Valsecia. Sección III, capítulo 20. Disponible en [30] Última actualización agosto de 2002.
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  • Other Languages
    العربية: ستاتين
    català: Estatina
    čeština: Statin
    Cymraeg: Statinau
    dansk: Statin
    Deutsch: Statin
    English: Statin
    eesti: Statiinid
    فارسی: استاتین
    suomi: Statiinit
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