Wiseblood received a mixed review from Allmusic writer Stephen Thomas Erlewine, who gave the album four stars out of five. He describes Wiseblood as the "closest Corrosion of Conformity have gotten to old-school heavy metal, yet their fondness for industrial soundbites and thrash-metal keeps the group sounding contemporary." However, Erlewine states that it "doesn't have half the hooks of its predecessor, which means it sounds great while its playing, but it disappears into the abyss once it's finished."
Despite receiving mixed reviews, Wiseblood is one of Corrosion of Conformity's most successful and best-selling albums to date, peaking at number 104 on the Billboard 200; this was the band's highest position on the chart for 22 years, until No Cross No Crown, which peaked at number 67. It also peaked at number two on the Heatseekers chart. One of the album's singles, "Drowning in a Daydream", peaked at number 27 on the Mainstream Rock chart.