On the first day of 2008, TNA updated their official website to publicize the official dates for all of their PPV events to take place that year. The next installment in the Turning Point chronology was scheduled for December 14, 2008. The date was later changed to December 21, and the location was announced as the TNA Impact! Zone in Orlando, Florida. In October 2008, three events were rescheduled: Genesis, Final Resolution, and Turning Point. The first moved was Turning Point to the Genesis event date of November 9, while Final Resolution was announced for some time in December. Genesis was later announced to be taking place in Charlotte, North Carolina on January 11, 2009. The song Indestructible by the rock band Disturbed was used as the official theme of the event. The promotional poster for the gathering, featuring Mick Foley, was released through PPV providers.
Turning Point featured eight professional wrestling matches that involved different wrestlers from pre-existing scripted feuds and storylines. Wrestlers were portrayed as either villains or heroes in the scripted events which built tension and culminated with a wrestling match or series of matches.
Heading into Turning Point, TNA's main storyline was an on-screen rivalry between professional wrestling veterans, who played the villains and called themselves The Main Event Mafia (Sting, Kurt Angle, Kevin Nash, Booker T, and Scott Steiner), and the younger talent of the company, who played the heroic characters and were led by A.J. Styles and Samoa Joe. Multiple smaller rivalries broke off from this storyline, such as one over the TNA World Heavyweight Championship between the reigning champion, Sting, and the challenger, Styles. It began on August 10 at TNA's Hard Justice PPV event when Sting assaulted Styles after his encounter with Angle. Sting then defeated Joe, an ally of Styles, at TNA's Bound for Glory IV PPV event on October 12 after an assist from Nash, which later sparked a rivalry between Joe and Nash. Sting's and Styles' rivalry soon escalated to a point where storyline co-owner of TNA Mick Foley announced on the October 30 episode of TNA's television program TNA Impact! that the two would fight for the championship at Turning Point.
The build to the encounter between Joe and Nash began in December 2007. On December 2, 2007 at the previous Turning Point event, Joe was scheduled to take part in a six-man tag team match, partnering with Nash and Nash's longtime real-life friend Scott Hall to face The Angle Alliance (Angle, Styles, and Tomko). Hall, however, missed the event citing "food poisoning", leaving Joe legitimately angered by the excuse. Joe went on to make an on-camera statement in the ring insulting Hall. Following the incident, TNA began a storyline in which Joe was unhappy with his position in the company for various reasons and had continuous conflicts with Nash. After time, Nash became Joe's on-screen mentor, which led to Joe defeating Angle on April 13 at TNA's Lockdown PPV event to become the new TNA World Heavyweight Champion. Joe and Nash's partnership seemed to come to a close after Nash disappeared from TNA television in mid-2008. He returned at Bound for Glory IV where he cost Joe the championship in his match against Sting. On the October 30 episode of Impact!, Foley announced that Joe would face Nash at Turning Point.
Another bout advertised for the event was Angle versus Abyss in a falls count anywhere match. At Bound for Glory IV, Angle lost to TNA founder and on-screen co-owner Jeff Jarrett with Foley as Special Guest Enforcer. On the Impact! after Bound for Glory IV, Angle challenged Jarrett to another match at Turning Point, however, Jarrett refused. Angered by Jarrett's refusal, Angle began assaulting several wrestlers in TNA to persuade Jarrett into accepting the challenge. On the October 23 episode of Impact!, Angle challenged Jarrett again to a rematch, which Jarrett again refused. Jarrett, however, recommended Abyss as Angle's opponent, who was a casualty of Angle's attacks the previous week. On the October 30 episode of Impact!, Angle fought Abyss in a contest which ended in a disqualification after Angle struck Abyss with a steel chair. Following their encounter, a match was promoted pitting Angle against Abyss in a falls count anywhere match at Turning Point.
On the October 23 episode of Impact!, Booker T introduced a new championship named the TNA Legends Championship and declared himself the inaugural champion. Afterwards, Christian Cage, who had remained neutral in the storyline, entered the arena and challenged Booker T to defend the championship against him at Turning Point. Booker T accepted after he added the stipulation that if Cage lost the encounter he would have to join The Main Event Mafia. Later on the October 30 episode of Impact!, the match was made official when it was promoted for the event.