Several sources indicate that the name Syria is derived from the 8th century BC Luwian term "Sura/i", and the derivative ancient Greek name: Σύριοι, Sýrioi, or Σύροι, Sýroi, both of which originally derived from Aššūrāyu (Assyria) in northern Mesopotamia. However, from the Seleucid Empire (323–150 BC), this term was also applied to The Levant, and from this point the Greeks applied the term without distinction between the Assyrians of Mesopotamia and Arameans of the Levant. Mainstream modern academic opinion strongly favours the argument that the Greek word is related to the cognate Ἀσσυρία, Assyria, ultimately derived from the AkkadianAššur. The Greek name appears to correspond to Phoenicianʾšr "Assur", ʾšrym "Assyrians", recorded in the 8th century BC Çineköy inscription.
The area designated by the word has changed over time. Classically, Syria lies at the eastern end of the Mediterranean, between Arabia to the south and Asia Minor to the north, stretching inland to include parts of Iraq, and having an uncertain border to the northeast that Pliny the Elder describes as including, from west to east, Commagene, Sophene, and Adiabene.
By Pliny's time, however, this larger Syria had been divided into a number of provinces under the Roman Empire (but politically independent from each other): Judaea, later renamed Palaestina in AD 135 (the region corresponding to modern-day Israel, the Palestinian Territories, and Jordan) in the extreme southwest; Phoenice (established in 194 AD) corresponding to modern Lebanon, Damascus and Homs regions; Coele-Syria (or "Hollow Syria") south of the Eleutheris river, and Iraq.