Yuri Lowenthal (right) does the voice of the character
Adi Granov helped design one of the character’s new suits known as the velocity suit
Several characters from Marvel Comics were considered to have their own game developed by Insomniac Games but the team's final choice was to adapt Spider-Man in his own video game. This was due to him and his true identity Peter Parker being more relatable to the staff than other Marvel characters such as Thor and Iron Man, a sentiment that Insomniac CEO Ted Price shared. Spider-Man then became the first licensed property by Insomniac in 22 years.
Intihar collaborated with a team of writers under lead writer Jon Paquette to create an original take on Spider-Man that remained true to the original. Paquette is cited to commonly subscribed to Spider-Man (The Amazing Spider-Man and Peter Parker: The Spectacular Spider-Man) and also Thor comic books at the "boonies" at a younger age before his time attending film school. Alongside Paquette, the story was written by Ben Arfman and Kelsey Beachum. Comic book and screenwriter Christos Gage co-wrote the script, and comic book writer Dan Slott provided additional story contributions. Insomniac researched different iterations of the character to understand what made a compelling Spider-Man story, after which Paquette said "okay let's forget all that stuff", aiming to not draw too much from any single version. One lesson the team took from the research was that whenever Spider-Man wins, Peter Parker loses, and vice versa. Intihar said that from conception, the game was designed to be as much Parker's story as Spider-Man's. The team deliberately avoided retelling Spider-Man's origin, reasoning that everyone knows Spider-Man was bitten by a radioactive spider.
Yuri Lowenthal provides the voice of Spider-Man / Peter Parker, but there was some initial reluctance to cast him as he had previously voiced a characteristically-different lead character in Sunset Overdrive and it was thought that he was not capable of providing a drastically different performance. Paquette trusted his acting ability however, and convinced the studio to cast him. Working with voice director Kris Zimmerman, Lowenthal tried to differentiate his voices for Parker in his civilian life where he is more gentle, and as Spider-Man, where he is more confident. As a result, he spent a large amount of time working on his performance to achieve a balance. Lowenthal worked with two stunt people throughout the game's development.
"When you see our Spider-Man suit it's instantly recognisable as Spider-Man. When you see the red and blue, the iconic eyes, the overall shape and form, there’s no mistaking that as Spider-Man. But… seeing that giant white spider on the red and blue suit, you know that’s different, that’s from a different universe. That's Insomniac's Spider-Man."
Bryan Intihar, 
Insomniac wanted to modernize the design of Spider-Man's costume while paying homage to the original design by Steve Ditko. The new advanced costume design the traditional red-and-blue color scheme, a large white spider symbol stretching across the torso, gauntlet-like gloves, and sneaker-style design based on athletic wear instead of knee-high boots. Art director Jacinda Chew said the design goal was to create what a "23-year-old, would-be superhero" would wear in 2018 New York City. Chew compared the outfit to compression wear, and said each color represented different materials. Blue is the most flexible, red is thicker for added protection from minor injury, and white offers the most protection, as it covers his chest, hands, and feet.
The velocity suit is another original suit and was designed by comic book artist Adi Granov. The suit is depicted with a glowing red-and-grey design and features metallic paneling.