The tour was announced on January 22, 2018 through a video featuring a montage of press clippings, early posters and press photos spanning Slayer's entire career. The first leg of the North American tour was announced the day after, which took place in May and June 2018 and included support from Lamb of God, Anthrax, Behemoth and Testament. The second leg of the North American tour was announced on March 5, 2018; this leg took place in July and August, and featured four out of five bands from the first leg (Slayer, Lamb of God, Anthrax and Testament) and Napalm Death as the replacement for Behemoth.
On February 20, 2018, Slayer announced the first European date of the farewell tour; it was announced that they would headline the Secret Solstice Festival in Reykjavík, Iceland in June. A European leg of the farewell tour took place in November and December 2018, with support provided by Lamb of God, Anthrax and Obituary. Guitarist Gary Holt had to miss the last four dates of this tour so that he could take care of his father who is near death; he was filled in by former Machine Head and Vio-lence guitarist Phil Demmel.
On June 24, 2018, Slayer was announced as one of the first five bands (alongside Manowar, Carcass, Mass Hysteria and Dropkick Murphys) confirmed to play the 2019 edition of Hellfest. This was the band's first show announced for 2019, and according to frontman and bassist Tom Araya and guitarist Kerry King, Hellfest will be their last-ever show in France. Slayer also played a one-off show in Mexico at ForceFest in October 2018.
Slayer will continue touring into 2019; in addition to international festival appearances, they plan to perform in areas the tour had not yet visited, including South America, Australia and Japan; Anthrax will be the supporting act on most of the dates. Slayer will also tour North America in May 2019, with Lamb of God, Amon Amarth and Cannibal Corpse as the opening acts.
On January 29, 2019, it was reported that Slayer is expected to play their final show in their hometown of Los Angeles at The Forum this December, with "three bands or more", including Anthrax, Testament and Exodus, as the openers. A North American tour presented by Live Nation will also reportedly take place in the summer of 2019.
On how long the farewell tour will last, Holt's Exodus bandmate Steve "Zetro" Souza commented, "I'm speculating it's gonna take a year and a half or two years to do the one final thing, but I believe it's finished. Everybody knows what I know; just because I'm on the outside, I have no insight on that." There has also been reported talk of Slayer participating in a rebooted Clash of the Titans tour with Megadeth, Sepultura and Testament, as well as at least one more Big Four show with Metallica, Megadeth and Anthrax.