The tour was announced on January 22, 2018 through a video featuring a montage of press clippings, early posters and press photos spanning Slayer's entire career. The first leg of the North American tour was announced the day after, which took place in May and June 2018 and included support from Lamb of God, Anthrax, Behemoth and Testament. The second leg of the North American tour was announced on March 5, 2018; this leg took place in July and August, and featured four out of five bands from the first leg (Slayer, Lamb of God, Anthrax and Testament) and Napalm Death as the replacement for Behemoth.
On February 20, 2018, Slayer announced the first European date of the farewell tour; it was announced that they would headline the Secret Solstice Festival in Reykjavík, Iceland in June. A European leg of the farewell tour took place in November and December 2018, with support provided by Lamb of God, Anthrax and Obituary. Guitarist Gary Holt had to miss the last four dates of this tour so that he could take care of his father who was nearing the end of his life; he was filled in by former Machine Head and Vio-lence guitarist Phil Demmel.
On June 24, 2018, Slayer was announced as one of the first five bands (alongside Manowar, Carcass, Mass Hysteria and Dropkick Murphys) confirmed to play the 2019 edition of Hellfest. This was the band's first show announced for 2019, and was said to be their last-ever show in France. Slayer also played a one-off show in Mexico at ForceFest in October 2018.
Slayer continued touring into 2019; in addition to international festival appearances, they performed in areas that the tour had not yet visited, including South America, Australia and Japan; Anthrax was the supporting act on most of the dates. Slayer toured North America in May 2019, with Lamb of God, Amon Amarth and Cannibal Corpse as the opening acts. The final North American leg of the tour will take place in November 2019, and will include support by Primus, Ministry and Philip H. Anselmo & The Illegals.
The band's final appearance in Chile on October 6, 2019 at the Santiago Gets Louder festival will mark the first time two of the "Big Four" (Slayer and Anthrax) have shared the stage with one of the members of the "Big Teutonic Four" of thrash, Kreator. Megadeth – who had not shared the stage with Slayer and Anthrax since the series of "Big Four" shows in 2010-2011 – was initially scheduled to perform at the festival, but cancelled due to Dave Mustaine's illness and was replaced by Kreator.
On how long the farewell tour would last, Holt's Exodus bandmate Steve "Zetro" Souza commented, "I'm speculating it's gonna take a year and a half or two years to do the one final thing, but I believe it's finished. Everybody knows what I know; just because I'm on the outside, I have no insight on that."