Zombie directed The Devil's Rejects (2005), a direct sequel to his prior film House of 1000 Corpses. The project received a more positive reception than its predecessor. His third studio album, Educated Horses (2006), was a departure from his earlier recordings. The album became his third to enter the top ten of the Billboard 200, though saw a decrease in sales when compared to his previous releases. Deciding to focus on his directing career, Zombie directed the horror film Halloween (2007), a remake of the 1978 horror classic of the same name. The film became Zombie's highest-grossing film to date, though was met with a generally negative critical reception. He later directed Halloween II (2009), which failed to match the success of its predecessor. He released the animated film The Haunted World of El Superbeasto that same year. Zombie returned to music with the release of his fourth studio album, Hellbilly Deluxe 2 (2010). The album peaked at number eight in the United States and sold over 200,000 copies in the country.
Since the beginning of his music career, Zombie's music and lyrics have featured notable horror and sci-fi themes. His live shows have been praised for their elaborate shock rock theatricality. Since beginning his solo career, Zombie has sold an estimated fifteen million albums worldwide.