She was active in the Los Angeles, California punk rock scene in her mid-teens, and was a founding member of The Bags in 1976. She left that band after a fallout with co-founder, Alice Bag. She began Legal Weapon in 1981, releasing an EP called No Sorrow.
Morrison joined The Gun Club in 1982, quitting after her second tour with them,. She then formed the band Fur Bible with Kid Congo Powers, performing as the opening act for Siouxsie and the Banshees. It was during this time Morrison was contacted by Andrew Eldritch, asking her to join The Sisters of Mercy. She performed on the 1986 album Gift (released under the group name The Sisterhood) and on The Sisters of Mercy's 1987 album Floodland.
According to Jennifer Park:
||the choice of Patricia Morrison as bassist — beginning with her work on Floodland (1987) — was not a decision made without weighing its aesthetic value. Music videos and promotional photographs showcased the perfect goth pin-up girl with her high arched eyebrows, black eyeliner, blood-red lips, teased-out hair, long black nails, and fetish-meets-renaissance wardrobe.
The Sisters of Mercy song "Lucretia My Reflection" was written by Eldritch about Morrison. The lyrics compare her to the historical figure of Lucrezia Borgia. She left the band in the early 1990s, claiming money that was owed by Eldritch was not paid.
In 1994, Morrison released a solo album, Reflect on This.
In 1996, she joined The Damned after bassist Paul Gray was injured by a fan in concert. That same year Morrison married the Damned's lead singer Dave Vanian. After giving birth to Emily Vanian in 2004, Morrison retired from the Damned.