Nyíregyháza is located in
Szabolcs-Szatmár-Bereg County in the northern Plain region (Szabolcs-Szatmár-Bereg county, Hajdú-Bihar county, and
Jász-Nagykun-Szolnok County). It is the most important city of
Northern Hungary, in all respects the center of the region. It is located in the center of
Nyírség as an agricultural town. The boundaries of the city are often understood as a very broad frame, because generally the near suburbs are included in them. It is located at the intersections of routes 4, 41, 36, and 38, therefore the city is easy to reach by road. Sub-Carpathia and Transylvania cannot be reached without passing the city.