The beginning of the empire is conventionally dated to the victory by its founder Babur over Ibrahim Lodi, the last ruler of the Delhi Sultanate, in the First Battle of Panipat (1526). During the reign of Humayun, the successor of Babur, the empire was briefly interrupted by the Sur Empire established by Sher Shah Suri. The "classic period" of the Mughal Empire began in 1556, with the ascension of Akbar to the throne. Some Rajput kingdoms continued to pose a significant threat to the Mughal dominance of northwestern India, but most of them were subdued by Akbar. All Mughal emperors were Muslims; Akbar, however, propounded a syncretic religion in the latter part of his life called Dīn-i Ilāhī, as recorded in historical books like Ain-i-Akbari and Dabistān-i Mazāhib. The Mughal Empire did not try to intervene in native societies during most of its existence, rather co-opting and pacifying them through concilliatory administrative practices and a syncretic, inclusive ruling elite, leading to more systematic, centralized and uniform rule. Traditional and newly coherent social groups in northern and western India, such as the Marathas, the Rajputs, the Pashtuns, the Hindu Jats and the Sikhs, gained military and governing ambitions during Mughal rule which, through collaboration or adversity, gave them both recognition and military experience.
Contemporaries referred to the empire founded by Babur as the Timurid empire, which reflected the heritage of his dynasty, and this was the term preferred by the Mughals themselves.
The Mughal designation for their own dynasty was Gurkani (Persian: گورکانیان, Gūrkāniyān, meaning "sons-in-law"). The use of Mughal derived from the Arabic and Persian corruption of Mongol, and it emphasised the Mongol origins of the Timurid dynasty. The term gained currency during the 19th century, but remains disputed by Indologists. Similar terms had been used to refer to the empire, including "Mogul" and "Moghul". Nevertheless, Babur's ancestors were sharply distinguished from the classical Mongols insofar as they were oriented towards Persian rather than Turco-Mongol culture.
Another name for the empire was Hindustan, which was documented in the Ain-i-Akbari, and which has been described as the closest to an official name for the empire. In the west, the term "Mughal" was used for the emperor, and by extension, the empire as a whole.