Lawrence is known for his work on the animated TV series SpongeBob SquarePants, on which he has long-running-roles as the voice of Sheldon Plankton and various recurring characters such as the Realistic Fish Head and Larry the Lobster. He physically appears as the live-action artist in "Frankendoodle".
He was the voice of Edward T. Platypus, Nurse Leslie, Dave, and Ping-Pong on Camp Lazlo. Lawrence also performed the voice of Filburt in Rocko's Modern Life and is recently the voice of the Announcer and Manant in The Aquabats! Super Show!. Lawrence is a standup comedian, cartoonist, writer-director, animator and producer on the television series Johnny Talk. He worked on The Ren and Stimpy Show in its second season as a layout assistant. Apart from his voice work he is a writer and, since season 10, the story editor on SpongeBob SquarePants and worked as a writer on Rocko's Modern Life and The Twisted Whiskers Show. He is also currently a writer and story editor on Mighty Magiswords, Cartoon Network's first original online series which later became a TV series in June 2016, and provides the voice of Ralphio among other characters.
As a comedian, Mr. Lawrence performed in New Jersey and Los Angeles, collaborating with comedian Jeremy Kramer and Boston comedy writer Martin Olson. Jeff "Swampy" Marsh, a storyboard writer for Rocko's Modern Life and co-creator of Phineas and Ferb, described Lawrence as bearing a "unique sense of humor", and that one "would really have to know Doug to understand (or not understand)" his style. Marsh says that the rationale for Lawrence's humor techniques and decisions "remain a mystery to us forever."