Lysergic acid diethylamide (LSD) Lysergide INN:
2D structural formula and 3D models of LSD
Clinical data Pronunciation /daɪ eθəl ˈæmaɪd/, /æmɪd/, or /eɪmaɪd/    Synonyms LSD, LSD-25, Acid, Delysid, others / AHFS Reference Pregnancy category US: (Risk not ruled out) C Dependence liability Low  Addiction liability Low-rare  Routes of administration , By mouth , under the tongue intravenous Drug class ( Hallucinogen ) serotonergic psychedelic ATC code Legal status Legal status data Pharmacokinetic Bioavailability 71%  Protein binding Unknown  Metabolism ( Liver ) CYP450  Metabolites 2-Oxo-3-hydroxy-LSD  Onset of action 30–40 minutes  half-life 3.6 hours   Duration of action 8–12 hours  Excretion Kidneys   Identifiers (6a R,9 R)- N, N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3- fg]quinoline-9-carboxamide 50-37-3 5761 17 DB04829 5558 8NA5SWF92O CHEBI:6605 ChEMBL263881 PDB ) RCSB PDB DTXSID1023231 100.000.031 Chemical and physical data Formula C 20 H 25 N 3 O Molar mass g·mol 323.440 −1 3D model ( Interactive image Melting point 80 to 85 °C (176 to 185 °F)
(verify) Lysergic acid diethylamide ( LSD), also known as acid, is a drug. hallucinogenic Effects typically include altered thoughts, feelings, and awareness of one's surroundings.  Many users  . see or hear things that do not exist Dilated pupils, increased blood pressure, and increased body temperature are typical.  Effects typically begin within half an hour and can last for up to 12 hours.  It is used mainly as a  and for recreational drug . spiritual reasons  
LSD does not appear to be addictive, although tolerance may occur with use of increasing doses.
 Adverse psychiatric reactions are possible, such as anxiety,  , and paranoia . delusions Distressing flashbacks might occur in spite of no further use, a condition called  . hallucinogen persisting perception disorder  Death is very rare as a result of LSD, though it occasionally occurs in accidents.  The effects of LSD are believed to occur as a result of alterations in the  . serotonin system As little as 20 micrograms can produce an effect.  In pure form, LSD is clear or white in color, has no smell, and is  . crystalline It breaks down with exposure to  . ultraviolet light 
About 10 percent of people in the United States have used LSD at some point in their lives as of 2017, while 0.7 percent have used it in the last year.
It was most popular in the 1960s to 1980s.  LSD is typically either swallowed or held under the tongue.  It is most often sold on  and less commonly as tablets or in blotter paper squares. gelatin There are no known treatments for addiction, if it occurs.  
LSD was first made by
in 1938 from Albert Hofmann , a chemical from the fungus lysergic acid . ergot  Hofmann discovered its hallucinogenic properties in 1943.  In the 1950s, the  (CIA) believed that the drug might be useful for Central Intelligence Agency , so they tested it on people, some without their knowledge, in a program called mind control . MKUltra LSD was sold as a medication for research purposes under the trade-name Delysid in the 1950s and 1960s.   It was listed as a  by the United Nations in 1971. schedule 1 controlled substance It currently has no approved medical use.  In Europe, as of 2011, the typical cost of a dose was between €4.50 and €25.  
Pink elephant blotters containing LSD
LSD is commonly used as a recreational drug.
LSD is considered an
because it can catalyze intense spiritual experiences, during which users may feel they have come into contact with a greater spiritual or cosmic order. Users sometimes report entheogen experiences. In 1966, out of body established the Timothy Leary with LSD as its League for Spiritual Discovery . sacrament   has written that religious and mystical experiences observed during LSD sessions appear to be Stanislav Grof indistinguishable from similar descriptions in the phenomenologically of the great religions of the world and the texts of ancient sacred scriptures . civilizations
LSD currently has no
in approved uses . medicine  A meta analysis concluded that a single dose was effective at reducing alcohol consumption in  . alcoholism LSD has also been studied in depression, anxiety, and drug dependence, with positive preliminary results.