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Lipogenesis is the process by which
acetyl-CoA is converted to fatty acids. The former is an intermediate stage in
metabolism of simple sugars, such as
glucose, a source of energy of living organisms. Through lipogenesis and subsequent triglyceride synthesis, the energy can be efficiently stored in the form of fats.
Fatty acids synthesis starts with
acetyl-CoA and builds up by the addition of two-carbon units. The synthesis occurs in the
cytoplasm of the cell, in contrast to the degradation (oxidation), which occurs in the
mitochondria. Many of the enzymes for the fatty acid synthesis are organized into a multienzyme complex called
fatty acid synthase. The major sites of fatty acid synthesis are adipose tissue and the liver.