The series was adapted into a 12-episode anime by TNK and Geneon Entertainment, which aired in Japan from October to December 2004. A drama CD, based on the anime version, was released on November 25, 2004 by Geneon. In North America the manga was licensed by Tokyopop and the anime by Geneon USA; the anime license was transferred to Sentai Filmworks in 2009. In 2010, the anime aired on the Anime Network as Destiny of the Shrine Maiden.
Himeko Kurusugawa and Chikane Himemiya are two high-school girls at the prestigious Ototachibana Academy in the fictional Japanese village of Mahoroba. They are also the reincarnations of the solar and lunar mikos. When their ancient enemy the Orochi (the eight-headed Yamata no Orochi of Japanese folklore) rises once more the girls' long-sealed personas awaken to defend the world. The Orochi awakens on the first day of October (Kannazuki, "the godless month," in the traditional Japanese lunar calendar), Himeko and Chikane's shared birthday. The first Orochi who tries to kill one of the mikos is Sōma Ōgami, Himeko's childhood friend (who is in love with her). However, after a blinding flash of light brings him to his senses, he rejects his fate and vows to defend Himeko against the other Orochi. The mikos must awaken Ame no Murakumo to combat the threat, while Sōma repels the Orochi's efforts to kill them.