JPL traces its beginnings to 1936 in the Guggenheim Aeronautical Laboratory at the California Institute of Technology (GALCIT) when the first set of rocket experiments were carried out in the Arroyo Seco. Caltech graduate students Frank Malina, Qian Xuesen,
Weld Arnold, and Apollo M. O. Smith, along with Jack Parsons and
Edward S. Forman, tested a small, alcohol-fueled motor to gather data for Malina's graduate thesis. Malina's thesis advisor was engineer/aerodynamicist Theodore von Kármán, who eventually arranged for U.S. Army financial support for this "GALCIT Rocket Project" in 1939. In 1941, Malina, Parsons, Forman, Martin Summerfield, and pilot Homer Bushey demonstrated the first jet-assisted takeoff (JATO) rockets to the Army. In 1943, von Kármán, Malina, Parsons, and Forman established the Aerojet Corporation to manufacture JATO rockets. The project took on the name Jet Propulsion Laboratory in November 1943, formally becoming an Army facility operated under contract by the university.
During JPL's Army years, the laboratory developed two deployed weapon systems, the MGM-5 Corporal and MGM-29 Sergeant intermediate range ballistic missiles. These missiles were the first US ballistic missiles developed at JPL. It also developed a number of other weapons system prototypes, such as the Loki anti-aircraft missile system, and the forerunner of the Aerobee sounding rocket. At various times, it carried out rocket testing at the White Sands Proving Ground, Edwards Air Force Base, and Goldstone, California. A lunar lander was also developed in 1938-39 which influenced design of the Apollo Lunar Module in the 1960s.
In 1954, JPL teamed up with Wernher von Braun's engineers at the Army Ballistic Missile Agency's Redstone Arsenal in Huntsville, Alabama, to propose orbiting a satellite during the International Geophysical Year. The team lost that proposal to Project Vanguard, and instead embarked on a classified project to demonstrate ablative re-entry technology using a Jupiter-C rocket. They carried out three successful sub-orbital flights in 1956 and 1957. Using a spare Juno I (a modified Jupiter-C with a fourth stage), the two organizations then launched the United States' first satellite, Explorer 1, on January 31, 1958.
JPL was transferred to NASA in December 1958, becoming the agency's primary planetary spacecraft center. JPL engineers designed and operated Ranger and Surveyor missions to the Moon that prepared the way for Apollo. JPL also led the way in interplanetary exploration with the Mariner missions to Venus, Mars, and Mercury. In 1998, JPL opened the
Near-Earth Object Program Office for NASA. As of 2013, it has found 95% of asteroids that are a kilometer or more in diameter that cross Earth's orbit.
JPL was early to employ female mathematicians. In the 1940s and 1950s, using mechanical calculators, women in an all-female computations group performed trajectory calculations. In 1961, JPL hired Dana Ulery as the first female engineer to work alongside male engineers as part of the Ranger and Mariner mission tracking teams.
JPL has been recognized four times by the Space Foundation: with the Douglas S. Morrow Public Outreach Award, which is given annually to an individual or organization that has made significant contributions to public awareness of space programs, in 1998; and with the John L. "Jack" Swigert, Jr., Award for Space Exploration on three occasions – in 2009 (as part of NASA's Phoenix Mars Lander Team), 2006 and 2005.