Isla de Maipo can be found in the
Chilean Central Valley approximately 40 km (25 mi) southwest of the metropolitan area of
Santiago and about 12 km (7 mi) from the city of
Talagante. The commune spans an area of 125.5 km2 (48 sq mi).
 In general, the commune is characterized as predominantly rural, which is reflected in its landscape of colonial houses, cultivated farms, vineyards, natural sites and the predominance of agricultural activities, which is carried out by the majority of its population.
 The Maipo River is the most important in the whole metropolitan area, because it supports the highest population density in Chile and is also the main stream which irrigates the area.