Four distinct awards have been named for writer, chemist, and humanist Isaac Asimov.
- The Isaac Asimov Award for Undergraduate Excellence in Science Fiction and Fantasy Short Story Writing, now known as the Dell Magazines Award, is an annual award open to undergraduate college students and given to the author of the best science fiction or fantasy short story. Established by the magazine Asimov's Science Fiction and the International Association for the Fantastic in the Arts, the award is typically given for character-driven stories of the type published in that magazine.
- The Asimov Prize (Italian: Premio Asimov) for popular science books, edited in Italian language. Established by Gran Sasso Science Institute, it is organised in collaboration with INFN. The winner is selected by a large jury of high school students, about 2300 in the last edition.  The 1st recipient (2016) was the chemist Peter Atkins, the 2nd one (2017) was the medical doctor Roberto Burioni, the 3rd ones (2018) are Helen Czerski and ex aequo, the 4th one the neurophysiologist Lamberto Maffei.
- The skeptical organization CSICOP created an Isaac Asimov Award, established in 1994 "to honor Asimov for his extraordinary contributions to science and humanity". The first recipient was Asimov's friend Carl Sagan. Stephen Jay Gould was also a winner.
- In 1998, the American Humanist Association awarded its first Isaac Asimov Award to Eugenie Scott. Awardees since then have included Robert Sapolsky, Neil deGrasse Tyson, Steve Wozniak, Richard Leakey and Lynn J. Rothschild.