The 1952 segment deals with Claire Donnelly (Demi Moore), a widowed nurse living in suburban Chicago, who becomes pregnant by her brother-in-law (Jason London) and decides to undergo abortion in order not to hurt her late husband's family. However, abortion at the time is strictly illegal. Claire eventually finds another nurse (C. C. H. Pounder) who provides her the phone number of a woman who can find her someone to perform the abortion. The woman on the phone tells Claire that the only trustworthy abortionist she knows is located in Puerto Rico, and Claire cannot afford the travel costs. After a failed attempt to end her pregnancy with a knitting needle, Claire eventually contacts a man who comes to her home and performs a clandestine procedure on her while she lies on top of a kitchen table. Claire finally manages to abort, but dies shortly afterwards due to hemorrhage.
The 1974 segment deals with Barbara Barrows (Sissy Spacek), a struggling and aging mother with four children and a policeman husband who works the night shift, who discovers she must welcome another addition to the family, despite having recently gone back to college. She considers abortion with the support of her teenage daughter (Hedy Burress) but ultimately chooses to keep the child.
The 1996 segment deals with Christine Cullen (Anne Heche), a college student who got pregnant by a married professor, decides on an abortion when he breaks up with her and only offers her money. After consulting with her roommate (Jada Pinkett), she makes an appointment with Dr. Beth Thompson (Cher). However, the abortion takes place during a violent protest, and an anti-abortion protester (Matthew Lillard) walks in on the operation and shoots Dr. Thompson.