Hormone replacement therapy (HRT), also known as menopausal hormone therapy (MHT), is for women suffering from menopausalsymptoms. It is based on the idea that the treatment may prevent discomfort caused by diminished circulating estrogen and progesteronehormones, or in the case of the surgically or prematurely menopausal, that it may prolong life and may reduce incidence of dementia. It involves the use of one or more of a group of medications designed to artificially boost hormone levels. The main types of hormones involved are estrogen, progesterone, or progestins, and sometimes, testosterone. It is often referred to as "treatment" rather than therapy.
Androgen replacement therapy (ART) in males with low levels of testosterone due to disease or aging. It is a hormone treatment often prescribed to counter the effects of male hypogonadism or who for men who have lost their testicular function to disease, cancer, or other causes. It is sometimes used for late-onset hypogonadism (so-called "andropause"), but the significance of a decrease in testosterone levels is debated and its treatment with replacement is controversial. The Food and Drug Administration (FDA) stated in 2015 that neither the benefits nor the safety of testosterone have been established in older men with low testosterone levels.