Aerial view of Home Hill, looking south.
Home Hill lies approximately 98 kilometres (61 mi) south of Townsville and 1,269 kilometres (789 mi) north of the state capital Brisbane on the Bruce Highway. It is a part of the Burdekin Region which includes the neighbouring town of Ayr. Both towns are governed by the Burdekin Shire Council.
The Burdekin River forms the locality's north-western boundary. The urban area is situated centrally within the locality surrounded by crop farming. The Bruce Highway passes through the town from the south-east to the north-west crossing the river via the Burdekin Bridge to Ayr. The North Coast railway line runs immediately parallel and south of the highway with the Home Hill railway station located in the town centre; it too crosses the river on the Burdekin Bridge. To the west of the town is Gardiner's Lagoon. Despite its name, the land in the locality is very flat.