Djedefhor was a son of Pharaoh Khufu and half-brother of pharaohs Djedefre and Khafre. Queen Meritites I is named in the tomb G 7220 of Djedefhor and it is possible she is his mother.
He is mentioned on an inscription in Wadi Hammamat, his name appears in a cartouche, written after the names of Khufu, Djedefre and Khafre, preceding the name of another of his brothers, Baufra. There is no evidence that either Djedefhor or Baufra ruled as a pharaoh, even though only pharaohs' names were written in cartouches during the 4th dynasty.
The Teachings of Djedefhor, a document of which only fragments remain, is attributed to him. Djedefhor seems to have been deified after his death. The wisdom text by Djedefhor was written as advice to his son, Prince Auibra.