Corticosterone

Corticosterone
Corticosterone-2D-skeletal.svg
Corticosterone molecule
Names
IUPAC name
(11β)-​11,​21-​dihydroxypregn-​4-​ene-​3,​20-​dione
Identifiers
3D model ( JSmol)
ChEBI
ChemSpider
DrugBank
ECHA InfoCard 100.000.018
MeSH Corticosterone
PubChem CID
UNII
Properties
C21H30O4
Molar mass 346.47 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Corticosterone, also known as 17-deoxycortisol and 11β,21-dihydroxyprogesterone, [1] is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. It is of minor importance in humans, except in the very rare case of congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency. [2]

Roles

In many species, including amphibians, reptiles, rodents and birds, corticosterone is a main glucocorticoid, [3] involved in regulation of energy, immune reactions, and stress responses.

However, in humans, cortisol is the primary glucocorticoid that is produced primarily in the zona fasciculata of the adrenal cortex. Corticosterone has only weak glucocorticoid and mineralocorticoid potencies in humans and is important mainly as an intermediate in the steroidogenic pathway from pregnenolone to aldosterone. Corticosterone is converted to aldosterone by aldosterone synthase, found only in the mitochondria of glomerulosa cells. Glomerulosa cells are found in the Zona glomerulosa, which is the most superficial region of endocrine cells in the adrenal cortex.

Corticosterone is the precursor molecule to the mineralocorticoid aldosterone, one of the major homeostatic modulators of sodium and potassium levels in vivo.

Other Languages
Deutsch: Corticosteron
español: Corticosterona
français: Corticostérone
Bahasa Indonesia: Kortikosteron
italiano: Corticosterone
македонски: Кортикостерон
português: Corticosterona
српски / srpski: Kortikosteron
srpskohrvatski / српскохрватски: Kortikosteron
svenska: Kortikosteron
Türkçe: Kortikosteron
中文: 皮质酮