Charles Édouard Guillaume (15 February 1861, Fleurier, Switzerland – 13 May 1938, Sèvres, France) was a Swiss physicist who received the Nobel Prize in Physics in 1920 in recognition of the service he had rendered to precision measurements in physics by his discovery of anomalies in nickel steel alloys. In 1919, he gave the fifth Guthrie Lecture at the Institute of Physics in London with the title "The Anomaly of the Nickel-Steels".
Guillaume is known for his discovery of nickel-steel alloys he named invar and elinvar. Invar has a near-zero coefficient of thermal expansion, making it useful in constructing precision instruments whose dimensions need to remain constant in spite of varying temperature. Elinvar has a near-zero thermal coefficient of the modulus of elasticity, making it useful in constructing instruments with springs that need to be unaffected by varying temperature, such as the marine chronometer. Elinvar is also non-magnetic, which is a secondary useful property for antimagnetic watches.
Guillaume is also known for the earliest estimation of the "radiation of the stars” in his 1896 paper "La Température de L'Espace (The Temperature of Space)". This is the first known reference to the concept that would later be known as the Cosmic Microwave Background. 
As the son of a Swiss horologist Guillaume took an interest in marine chronometers. For use as the compensation balance he developed a slight variation of the invar alloy which had a negative quadratic coefficient of expansion. The purpose of doing this was to eliminate the "middle temperature" error of the balance wheel.