In the Pre-Columbian era, Central America was inhabited by the indigenous peoples of Mesoamerica to the north and west and the Isthmo-Colombian peoples to the south and east. Soon after Italian explorer Christopher Columbus's voyages to the Americas, the Spanish began to colonize the Americas. From 1609 until 1821, most of the territory within Central America—except for the lands that would become Belize and Panama—was governed by the Viceroyalty of New Spain from Mexico City as the Captaincy General of Guatemala. After New Spain achieved independence from Spain in 1821, some of its provinces were annexed to the First Mexican Empire, but soon seceded from Mexico to form the Federal Republic of Central America, which lasted from 1823 to 1838. The seven states finally became independent autonomous states: beginning with Nicaragua, Honduras, Costa Rica, and Guatemala (1838); followed by El Salvador (1841); then Panama (1903); and finally Belize (1981). Even today, people in Central America sometimes refer to their nations as if they were provinces of a Central American state. For example, it is not unusual to write "C.A." after the country names in formal and informal contexts and the automobile licence plates of many of the countries in the region show the legend "Centroamerica" in addition to the country name.
Middle America is usually thought to comprise Mexico to the north of the 7 states of Central America as well as Colombia and Venezuela to the south. Usually, the whole of the Caribbean to the northeast, and sometimes the Guyanas, are also included. According to one source, the term "Central America" was used as a synonym for "Middle America" at least as recently as 1962.
For the people living in the five countries formerly part of the Federal Republic of Central America there is a distinction between the Spanish language terms "América Central" and "Centroamérica". While both can be translated into English as "Central America", "América Central" is generally used to refer to the geographical area of the seven countries between Mexico and Colombia, while "Centroamérica" is used when referring to the former members of the Federation emphasizing the shared culture and history of the region.
In Portuguese as a rule and occasionally in Spanish and other languages, the entirety of the Antilles is often included in the definition of Central America (the Portuguese Wikipedia article for the Antilles offers, in fact, América Central Insular as an alternative name), which is its own region to be distinguished from North America and South America alike. Indeed, the Dominican Republic is a full member of the Central American Integration System.