April 7 – 'Tacky's War', a slave rebellion, begins in Jamaica and lasts for 18 months. During the uprising, 60 white residents are killed and more than 400 black rebels die in the suppression of the revolt. Another 500 are deported to the British Honduras. 
April 10 – France's Minister of the Navy Nicolas René Berryer finally receives permission to send ships to assist French forces at Quebec, and a fleet of six ships under the command of Captain François Chenard de la Giraudais of the French frigate Machault departs Bordeaux, albeit too late to prevent the loss of New France to the British. 
April 11 – The Burmese Army, under the command of King Alaungpaya, reaches the outskirts of Siam's capital, Ayutthaya, but then retreats rather than laying siege to the city. 
April 12 – Two of the six French ships run into a British blockade led by Britain's Admiral Edward Boscawen. Of the remaining four, one sinks before it can reach North America. 
April 27 – British Army Brigadier General James Murray marches a force of 3,500 men toward Saint-Augustin to confront Marshal Lévis and the French Army. 
April 28 – British defenders and the French Army clash at the Battle of Sainte-Foy to determine the future control of Quebec. General Murray is forced to retreat after the British suffer 259 deaths and 845 wounded, while the French under Marshal Lévis suffer 193 deaths and 640 wounded. 
April 29 – Representatives of the remaining Penobscot Indian tribes in Maine and New Brunswick make peace with the British at Fort Pownal in Newfoundland. 
May 16 – Three Royal Navy ships, under the command of Commodore Robert Swanton on HMS Vanguard, arrives to break siege of Quebec before Marshal Lévis can recapture the city from the British.
May 17 – Captain Giraudais's French fleet reaches the Gaspé Peninsula of northeast Quebec and captures seven British merchant ships, but Giraudais learns that the British have already preceded him up the St. Lawrence River and diverts to Chaleur Bay at Newfoundland. 
December 4 – For the first time since the surrender of Fort Detroit by France, British authorities meet nearby at a Native American council house the site with delegates from various Indian tribes that had fought as allies of the French Army, such as the Wyandot and Ottawa Indians, and with tribes that had formerly been allies of the British. The European and Native American representatives open the peace conference with the presentation by the Indians to the British of a wampum belt, and the pronouncement from the principal chief that "The ancient friendship is now renewed, and I wash the blood off the earth that had been shed during the present war, that you may bury the war hatchet in the bottomless pit." 
December 6 – The siege of Pondicherry, a stronghold of France in India, is begun by British Army Lieutenant General Eyre Coote. The French commander, General Thomas Lally, is finally forced to surrender Pondicherry to the British on January 15, 1761. 
December 18 – In the wake of Tacky's War by African-born rebels, the Assembly of the British colony of Jamaica outlaws the African religious practice of obeah, with penalties ranging from banishment from the colony to execution. The legislation specifically bans use of contraband associated with obeah, including "animal blood, feathers, parrots' beaks, dogs' teeth, alligators' teeth, broken bottles, grave dirt, rum, and eggshells". 
April 4 – A severe epidemic of influenza breaks out in London and "practically the entire population of the city" is afflicted; particularly contagious to pregnant women, the disease causes an unusual number of miscarriages and premature births. 
April 14 – Thomas Boone is transferred south to become the Royal Governor of South Carolina after proving to be unable to work with the local assembly as the Royal Governor of New Jersey. 
June 6 – (May 26 old style); A transit of Venus occurs, and is observed from 120 locations around the Earth. In his observations by telescope at St. Petersburg, Mikhail Lomonosov notes a ring of light around the planet's silhouette as it begins the transit, and becomes the first astronomer to discover that the planet Venus has an atmosphere. 
August 6 – The parlement of Paris votes to close all colleges, associations and seminaries associated with the Jesuit Order, following a long campaign by Louis-Adrien Le Paige. 
August 11 – Two years after his marriage to Martha Custis and his move to Mount Vernon, retired British Army General George Washington advertises a reward in the Maryland Gazette for the capture of four fugitive slaves, named Cupid, Peros, Jack, and Neptune, averring that they had escaped "without the least suspicion, provocation, or difference with anybody". 
October 5 – William Pitt is dismissed from his position as Secretary of State for the Southern Department (which administers Britain's American colonies) after having been a powerful part of a coalition government with the Prime Minister, the Duke of Newcastle. King George III, who had ascended the throne a year earlier, despises both men and takes the action two weeks after his formal coronation.
October 30 – British Army Colonel Henry Bouquet issues the first proclamation against British settlement on Indian lands in America. 
November 7 – The New London Harbor Light is first lit to guide ships into the Connecticut harbor; the lighthouse, only the fourth to be built has been in continuous operation for more than 250 years.
November 26 – A 500-man force from the Army of Spain brings the revolt of Mexico's Maya population to an end, capturing the Yucatan village of Cisteil, killing about 500 of the 2,500 Mayan defenders and losing 40 of their own.  The Spaniards arrest 254 people, including Jacinto Canek, who had proclaimed himself as King Canek Montezuma of the Mayas. Canek and eight other rebellion leaders are executed less than three weeks later.
March 5 – A Royal Navy fleet with 16,000 men departs Britain from Spithead and sets sail toward Cuba in order to seize strategic Spanish Empire possessions in the Americas. 
March 10 – Jean Calas, a 68 year old French merchant convicted unjustly of murdering his son because of religious differences, is brutally executed on orders of the parlement court of Toulouse. After his legs and hips are broken and crushed, Calas is tortured on the breaking wheel (la roue), to remain "in pain and repentance for his crimes and misdeeds, for as long as it shall please God to keep him alive." 
March 17 – The first Saint Patrick's Day Parade in New York City takes place in lower Manhattan, inaugurating an annual tradition; the Ancient Order of the Hibernians organization later becomes the sponsor of the event, which attracts as many a 300,000 marchers in some years. 
March 20 – Innovative publisher Samuel Farley launches the weekly newspaper The American Chronicle, the seventh in New York City. 
April 5 – France issues a new ordinance requiring all black and mixed-race Frenchmen to register their identity information with the offices of the Admiralty Court, upon the advice of Guillaume Poncet de la Grave, adviser to King Louis XV. The new rule, which requires both free and enslaved blacks and mulattoes to list data including their age, surname, purpose for which they are residing in France, whether they have been baptized as Christians, where they emigrated from in Africa and the name of the ship upon which they arrived. Previously, the Declaration of 1738 required slave-owners to register their slaves, but placed no requirement on free people. 
June 8 – Cherokee Indian war chief Ostenaco and his two aides, Standing Turkey (Cunneshote) and Pouting Pigeon, are received by King George III. They had arrived three days earlier at Plymouth on the British frigate Epreuvre as guests of the Timberlake Expedition of Henry Timberlake, to discuss terms of peace with the British government. 
December 4 – Less than six months after becoming Russia's Empress, Catherine the Great announces that almost all foreigners are welcome to travel to and settle in Russia, and waives previous requirements that new residents must be members of the Russian Orthodox Church; however, the manifesto adds the phrase kromye Zhydov-- "except the Jews". 
December 22 – Catherine follows the waiver of religious requirement for Russian immigration with a 190-word invitation, translated into various European languages, that invites Europeans to build settlements along arable, but undeveloped, land in southern Russia along the Volga River; when the invitation attracts little notice, she follows on July 22 with a longer manifesto promising free travel expenses and a written guarantee of rights. 
April 19 – Teedyuscung, known as the "King of the Delaware Indians" (the Lenape tribe) is assassinated by arsonists who burn down his home in Pennsylvania while he is sleeping, in an apparent retaliation for signing the Treaty of Easton to relinquish Lenape claims to the Province of New Jersey.
April 23 – The controversial Issue 45 of John Wilkes's satirical newspaper The North Briton is published as a response to a speech four days earlier by King George III praising the end of the Seven Years' War. In what will become a test case for freedom of speech, Wilkes, a member of Parliament, is arrested for libel of the King and imprisoned, then exiled to France.
April 27 – Outraged by the British success in taking control of land in North America formerly occupied by the French, Pontiac, chief of the Odawa people, convenes a conference near Detroit and convinces the leaders of 17 other nations of the need to attack British outposts.
March 20 – After the British victory in the French and Indian War, the first post-war British expedition to explore the newly-acquired territories east of the Mississippi River comes under attack by Tunica warriors. The 340 British Army men, under the command of Major Arthur Loftus, were at a spot south of Natchez, Mississippi and were forced to flee in their boats back toward the port of New Orleans while under fire from an unknown number of Tunicas firing from both banks.
April 21 – Residents of French Louisiana are informed for the first time that they will come under Spanish rule as the result of a secret agreement of November 13, 1762 whereby France has ceded all of its North American territory west of the Mississippi River. The Spanish, however, do not take possession until August 17, 1769.
April 27 – Eight-year-old child prodigy Wolfgang Amadeus Mozart performs a private concert before King George III and Queen Charlotte in Great Britain, and has an encore on May 19.
July 6 – The last British troops depart Havana, Cuba, two years after having captured it from Spain during the Seven Years' War. The removal of troops follows the treaty between the two Kingdoms, with Spain ceding West Florida to Great Britain in return for the Havana withdrawal.
July 8 – The Niagara Conference begins at the invitation of Sir William Johnson, the British Superintendent of Indian Affairs for the northern district, who hosts "one of the largest conventions of red men ever held on the continent" to negotiate the end of the hostilities from the French and Indian War. Reportedly, 2,000 representatives of the North American tribes meet at upstate New York come from distances ranging "From Dakota to Hudson's Bay, and from Maine to Kentucky." 
July 11 – Conditional repatriation of the Acadians in Canada, French colonists who took up arms against the British during the war, is approved by order of King George III on advice of the Privy Council. The Council offers settlement to any Acadians willing to take an oath of allegiance to the British Crown and that those living in New Brunswick are to "be allowed to settle in Nova Scotia, but that they should be dispersed in small numbers in various localities." 
Chief Pontiac, participating in an armed conflict with other native tribes against British military, participates in a dialogue and exchange with the military of Britain, resulting eventually in a negotiated peace treaty.
Frederick the Great, the King of Prussia, issues a decree abolishing the historic punishments against unmarried women in Germany for "sex crimes", particularly the Hurenstrafen (literally "whore shaming") practices of public humiliation. 
Isaac Barré, a member of the British House of Commons for Wycombe and a veteran of the French and Indian War in the British American colonies, coins the term "Sons of Liberty" in a rebuttal to Charles Townshend's derisive description of the American colonists during the introduction of the proposed Stamp Act. MP Barré notes that "They fled from your tyranny to a then uncultivated and unhospitable country... And yet, actuated by the principles of true English liberty, they met all these hardships with pleasure, compared with those they suffered in their own country, from the hands of those who should have been their friends." American colonists adopt the term for their own organization after reading the accounts of Barré's speech. 
February 14 – Spain's five-member "special junta", appointed by Prime Minister Jerónimo Grimaldi, delivers its report regarding "ways to address the backwardness of Spain's commerce with its colonies and with foreign nations". The report provides detailed orders to be delivered to José de Gálvez, the visitador general in charge of New Spain. 
March 9 – After a public campaign by the writer Voltaire, judges in Paris posthumously exonerate Jean Calas of murdering his son. Calas had been tortured and executed in 1762 on the charge, though his son may have committed suicide.
March 24 – Great Britain passes the Quartering Act, requiring private households in the thirteen American colonies to house British soldiers if necessary.
April 4 – At Fort Tombecbe, near what is now the town of Epes, Alabama, representatives of the British Empire and of the Choctaw Indian tribe in Mississippi sign a peace treaty in the wake of French cession of claims to the British. A boundary is fixed between land to be occupied by the Choctaws and for lands which British settlers can use; in addition, the British agree to provide a police official and a gunsmith at Fort Tombecbe for the Choctaws to use for trespassing complaints and for weapons repairs. By 1775, however, the Choctaws are outnumbered in Mississippi. 
April 14 – Three days after getting the news that the Stamp Act has passed, American colonists invade the British Army arsenal near the New York City Hall and sabotage guns inside by spiking them. 
April 26 – At Saint Petersburg, German engineer Christian Kratzenstein presents to the Russian Academy of Sciences a perfected version of the arithmetical machine originally invented by Gottfried Leibniz. Kratzenstein claims that his machine solves the problem with the Leibniz machine has with calculations above four digits, perfecting the flaw where the machine is "prone to err whenever it is necessary to make a number of 9999 move to 10000", but the machine is not developed further. 
May 18 – Not long after British rule has started over the formerly French colony of Quebec, an accidental fire destroys one quarter of the town of Montreal. 
May 26 – During a stroll in the park "on a fine Sabbath afternoon" at Glasgow Green, Scottish engineer James Watt receives the inspiration that provides the breakthrough in his development of the steam engine; he recounts later that "The idea came into my mind, that as steam was an elastic body it would rush into a vacuum, and if a communication was made between the cylinder and an exhausted vessel, it would rush into it, and might be there condensed without cooling the cylinder... I had not walked further than the Golf-house when the whole thing was arranged in my mind." 
July 12 – On orders of Chief Pontiac, War Chief Wahpesah of the Kickapoo people releases British Indian Affairs negotiator George Croghan from 35 days of detention.  At the same time, Pontiac authorizes a Shawnee Chief, Nanicksah, to sign a treaty with the British on behalf of the Great Lakes tribes, settling the French and Indian War. 
July 21 – Having eliminated all of his rivals for leadership of Persia, Karim Khan Zand returns in triumph to his home in Shiraz and makes it his capital, then begins construction of citadels, mosques, schools and other buildings. 
July 30 – At Yale College, eight students attack the residence of Yale's President Thomas Clap because of his promotion of "New Light"Calvinist doctrine; and "with Evil Intent" and "with Strong hand burst and take off the gates of the yard of the mansion house and Carry away and with Screaming and Shouting... throw into said House Numbers of large stones with Cattles Horns into the windows of said House."  The students plead guilty and pay nominal fines, and Clap resigns at the end of the 1765-66 school year.
January 20 – Outside of the walls of the Thailand capital of Ayutthaya, tens of thousands of invaders from Burma (under the command of General Ne Myo Thihapate and General Maha Nawatra) are confronted by Thai defenders led by General Phya Taksin. The defenders are overwhelmed and the survivors take refuge inside Ayutthaya. The siege continues for 15 months before the Burmese attackers collapse the walls by digging tunnels and setting fire to debris. The city falls on April 9, 1767, and King Ekkathat is killed.
February 5 – An observer in Wilmington, North Carolina reports to the Edinburgh newspaper Caledonian Mercury that three ships have been seized by British men-of-war, on the charge of carrying official documents without stamps. The strict enforcement causes seven other ships to leave Wilmington for other ports.
February 15 – Protesting against the Stamp Act 1765, members of the New York City Sons of Liberty travel to Pennsylvania and set fire to a British supply of tax stamps before the stamps can be taken to distributors in the province of Maryland. 
February 20 – The Pennsylvania Gazette reports that a British sloop off Wilmington, North Carolina, has seized a sloop sailing from Philadelphia, and another sailing from Saint Christopher, on the charge of carrying official documents without stamps. In response, local residents threaten to burn a Royal Man-of-War attempting to deliver stamps to Wilmington, forcing the ship to return to the mouth of the Cape Fear River.
May 29 – In a paper read to the Royal Society, British theoretical chemist Henry Cavendish first describes his process of producing what he refers to as "inflammable air" by dissolving base metals such as iron, zinc and tin in a flask of sulfuric acid or hydrochloric acid, drawing the conclusion that the vapor that was released is different from air. Seven years later, French chemist Antoine Lavoisier bestows the name "hydrogen" on the gas.
June 4 – On the occasion of the 28th birthday of King George III, members of the Sons of Liberty in Manhattan erect a liberty pole as a protest for the first time. The historic symbol, a tall "wooden pole with a Phrygian cap" is placed "on the Fields somewhere between Broadway and Park Row". British soldiers cut down the pole in August.
August 10 – During the occupation of New York, members of the 28th Foot Regiment of the British Army chop down the liberty pole that was erected by the Sons of Liberty on June 4. The Sons of Liberty put up a second pole the next day, and that pole is cut down on August 22.
August 13 – A hurricane sweeps across the French island colony of Martinique, killing more than 400 people and destroying the plantation owned by Joseph-Gaspard de La Pagerie, the father of the future French Empress Joséphine.
September 1 – The revolt in Quito (at this time part of Spain's Viceroyalty of Nueva Granada; the modern-day capital of Ecuador) is ended peacefully as royal forces enter the city under the command of Guayaquil Governor Pedro Zelaya. Rather than seeking retribution from the Quito citizens over their insurrection that has broken the monopoly over the sale of the liquor aguardiente, Zeleaya oversees a program of reconciliation.
September 23 – John Penn, the Colonial Governor of Pennsylvania and one of the four Penn family owners of the Pennsylvania land grant, issues a proclamation forbidding British American colonist residents from building settlements on lands in the west "not yet purchased of the Nations" of the Iroquois Indians.
October 4 – France formally cedes its rights to the Malouines Islands to Spain. On March 24, Spain renames the islands the Malvinas, and in 1833, the United Kingdom captures the two islets from Argentina and renames them the Falkland Islands.
November 27 – A British sloop-of-war is searching all vessels passing near Cape Lookout, North Carolina, and some vessels have been seized, according to an observer in New York City, in the Province of New York, reporting to the Pennsylvania Gazette.
March 15 Andrew Jackson, the seventh president, was born.
March 24 – Spain acquires control of what are now called the Falkland Islands from France, compensating French Admiral Louis Antoine de Bougainville for the money spent on the construction of the settlement at Fort Saint Louis. The islands, named les Îles Malouines by the French, are renamed las Islas Malvinas by the Spanish, and Fort Saint Louis is renamed as Puerto Soledad. In 1816, Argentina declares independence from Spain and takes the Malvinas; and in 1833, Britain's Royal Navy captures the islands from the Argentines and renames them the Falklands, and renames Puerto Soledad as Port Louis.
March 31 – Enforcement begins of the February 27 decree by King Carlos III of Spain, ordering the suppression of the Society of Jesus (the Jesuits) in the colonies in Spanish America. Over the next few months approximately 2,200 Jesuit priests and missionaries are deported.
May 16 – Ahmed al-Ghazzal, the emissary from Sultan Mohammed ben Abdallah of Morocco to the Spanish Empire, makes a triumphant return to Marrakesh with almost 300 Muslims who had been held captive in Spain, as well as sacred Islamic manuscripts that had been seized by the Spanish in 1612. The negotiation of the release had started with al-Ghazzal's meeting with Spain's King Carlos III on August 21, 1766.
May 31 – The Genoese island of Capraia is conquered by the Corsican Army after a ten-week campaign.
October 9 – Surveying of the "Mason–Dixon line", which will later become the traditional division between the northern and southern states of the United States, is completed by Charles Mason and Jeremiah Dixon after four years, initially to settle a boundary dispute between the colonies of Delaware, Pennsylvania and Maryland. The survey party is halted at Dunkard Creek when a chief of the Mohawk Indians tells them that they are in Native American territory and that the Mohawks guiding the property "would not proceed one step further Westward"; the line, slightly west the 80th meridian west, is now part of the boundary between Pennsylvania and West Virginia.
October 17 – Šćepan Mali, nicknamed "Stephen the Little", is selected as the legislature at Podgorica to be the Tsar of Montenegro, representing "a short but an important break in the succession of the Petrovic dynasty".
October 24 – In France, several anti-Jewish regulations in place since October 12, 1661, are repealed by the King's Council that advises Louis XV of France. While Jewish merchants are still prohibited from owning their own retail stores, they are allowed to sell merchandise on credit to gentile merchants at legal interest rates, to legally enforce debts, and to sell jewelry.
October 28 – A boycott, of 38 types of goods  imported from England, is resolved by Boston merchants meeting at Faneuil Hall as a response to the taxes imposed by Great Britain, and one of the first "Buy American" campaigns is started in order to encourage the purchase of items manufactured and produced in the 13 colonies. Copies of the agreement, to be signed by participating merchants, are circulated beyond the Province of Massachusetts Bay to other colonial provinces in New England.
November 14 – The Timucua Indian tribe, native to central Florida, becomes extinct with the death of the last speaker of the Timucuan language, Juan Alonso Cabale. Eight years earlier, the last 95 surviving Timucuan people had been forcibly relocated by the Spanish colonial government to Guanabacoa, a township in western Cuba.
November 20 – The new American Colonies Act 1766, commonly called the "Declaratory Act", goes into effect, virtually providing for Great Britain's Parliament to govern lawmaking in 13 colonies and exacerbating tensions there.
November 29 – The Archduchess Maria Theresa of Austria, in her capacity as Queen of Hungary, issues an edict against the Romani people (commonly called the gypsies), prohibiting them from marrying and calling for gypsy children to be taken away by the government so that they can be brought up by Christian families, a proclamation that "produced little or no effect in comparison with the trouble involved". The World's History: A Survey of Man's Record, Volume V: South-Eastern and Eastern Europe edited by H. F. Helmolt (William Heinemann, 1907) p423
December 29 – Oconostota and Attakullakulla arrive at Johnstown, New York where they, along with leaders of the Six Nations of the Iroquois Confederacy (the Mohawk, Onondaga, Oneida, Cayuga, Seneca and Tuscarora tribal nations) meet with Sir William Johnson to begin peace negotiations with the British Empire.
March 1 – King Louis XV of France decrees that all cities and towns in the kingdom will be required to post house numbering on all residential buildings, primarily to facilitate the forced quartering of troops in citizens' homes.
June 14 – The largest mass meeting ever held in New England, up to that time, takes place at the Old South Church to support a petition demanding that the British remove a ship which has been hindering navigation in Boston Harbor.
July 25 – The Imperial Court of China's Emperor Qianlong and his three senior grand councilors, Fuheng, Yenjisan and Liu T'ung-hsun, issues a directive to officials in the Zhejiang, Jiangsu and Shandong provinces warning them about the need to respond to rumors of sorcery.
August 7 – The palace of the Ottoman Grand Vizier is destroyed by a fire in Constantinople 
August 26 – Captain Cook's ship The Endeavour sets sail.
August 27 – Almost all merchants and traders in the British colony of New York sign a pact not to import British manufactured goods as long as the Townshend Acts are in effect, nor to do business with nonassociators to the pact.
October 1 – The British Army's 29th Infantry Regiment of foot soldiers, which will later carry out the Boston Massacre on March 5, 1770, arrives in Boston Harbor along with three other regiments. The 700 foot soldiers march through the Massachusetts colony's capital as a show of force and begin their occupation. Within a year, there will be "nearly 4,000 armed redcoats in the crowded seaport of 15,000 inhabitants." 
October 15 – A powerful hurricane sweeps across Cuba during the Festival of Santa Teresa, killing hundreds of people. Spain's King Carlos III begins a precedent of ordering the colonial government to fund disaster relief, a task previously left to the Catholic Church.
September – Massive droughts in Bengal lead to the Bengal famine of 1770, in which ten million people, a third of the population, will die, the worst natural disaster in human history (in terms of lives lost). The Maharajah of Mysore forces the British to agree to a treaty of mutual assistance in view of the famine, but the British East India Company increases its demands on the Bengali people to keep profits up.
October 9 – In the first encounter between the Māori people and Europeans (at the future site of Gisborne, New Zealand), one Maori is shot and killed after he steals a sword from one of the officers of the Cook expedition. Several more Maori are killed in fighting the next day.